Drug Interactions With Lisinopril-Hydrochlorothiazide

Taking different medications together may lead to potentially harmful drug interactions. With lisinopril-hydrochlorothiazide, an interaction may occur if the drug is taken with lithium, nonsteroidal anti-inflammatory drugs, potassium-sparing diuretics, or oral diabetes medications. Drug interactions with lisinopril-hydrochlorothiazide may result in electrolyte imbalances, extremely low blood pressure, high blood sugar levels, or other health problems.

 

Lisinopril-Hydrochlorothiazide Drug Interactions: An Overview

 Lisinopril-hydrochlorothiazide (available as a generic or under the brand names Prinzide® or Zestoretic®) potentially has a number of other medicines with which it may interact. Some lisinopril-hydrochlorothiazide interactions can involve:
 
o Amobarbital (Amytal®)
o Butabarbital (Butisol Sodium®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
o Thiopental (Pentothal®)
  • Narcotics, such as codeine, morphine, oxycodone, and hydrocodone
     
  • Cholestyramine (Prevalite®, Questran®, Questran® Light, LoCholest®)
     
  • Colestipol (Colestid®)
     
  • Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
     
  • Norepinephrine
     
  • Corticotropin (Acthar®)
     
  • Muscle relaxants, such as tubocurarine.
     
(Drug Interactions With Lisinopril-Hydrochlorothiazide Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;