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Specific Interactions With Losartan-Hydrochlorothiazide

Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
If you are taking both losartan-hydrochlorothiazide and lithium, your body may metabolize the drugs differently than intended and increase the lithium levels in the blood. Your healthcare provider may choose to monitor your blood lithium levels more frequently.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking both NSAIDs and losartan-hydrochlorothiazide may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of losartan-hydrochlorothiazide. For your particular situation, talk to your healthcare provider about using NSAIDs and losartan-hydrochlorothiazide together.
 
Fluconazole (Diflucan)
If you are taking fluconazole and losartan-hydrochlorothiazide together, your body may metabolize losartan-hydrochlorothiazide differently than intended. This can cause an increased level of losartan-hydrochlorothiazide in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your losartan-hydrochlorothiazide dose as needed.
 
Insulin
Taking insulin with losartan-hydrochlorothiazide may cause high blood sugar (hyperglycemia). For your particular situation, your healthcare provider may monitor you more closely and/or adjust your dose of insulin as needed.
 
Oral Diabetes Medication
Taking an oral diabetes medication with losartan-hydrochlorothiazide may increase blood sugar levels. For your particular situation, your healthcare provider may monitor you more closely and/or adjust your dose of diabetes medications as needed.
 
Other Blood Pressure Medicine
When taking losartan-hydrochlorothiazide with another high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this losartan-hydrochlorothiazide interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
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