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Effectiveness and Dosing Guidelines for Losartan-Hydrochlorothiazide

Losartan-Hydrochlorothiazide Effects

A blood pressure reading consists of two numbers -- for example: 120/80. The top number is known as the systolic blood pressure and the bottom number is the diastolic blood pressure. During clinical studies in people taking losartan-hydrochlorothiazide, systolic blood pressure (the top number) decreased by up to 16 mmHg and diastolic blood pressure (the bottom number) decreased by up to 9 mmHg. The higher the dose of losartan-hydrochlorothiazide, the greater the drop in blood pressure.
By lowering blood pressure, losartan-hydrochlorothiazide can decrease the risk of developing health problems, such as a heart attack or stroke, that are caused by long-term high blood pressure (see Effects of High Blood Pressure).

When and How Do I Take Losartan-Hydrochlorothiazide?

Some general considerations for when and how to take losartan-hydrochlorothiazide include:
  • Losartan-hydrochlorothiazide comes in tablet form. It is taken once a day.
  • Losartan-hydrochlorothiazide may be taken with or without food.  


  • Losartan-hydrochlorothiazide should be taken at the same time each day to maintain an even level of the medicine in your blood.
  • For losartan-hydrochlorothiazide to work properly, you have to take it as prescribed. The drug will not work if you stop taking it.

Losartan-Hydrochlorothiazide Dosing

The dose of losartan-hydrochlorothiazide your healthcare provider recommends will vary depending on a number of factors, including:
  • Other medical conditions you may have
  • Other medications you may currently be taking
  • How you respond to losartan-hydrochlorothiazide.
As with any medication, do not adjust your losartan-hydrochlorothiazide dose unless your healthcare provider specifically instructs you to do so.
(Click Dosing With Losartan-Hydrochlorothiazide for more information about dosing guidelines for losartan-hydrochlorothiazide.)
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