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Effects of Losartan-Hydrochlorothiazide and Specific Uses

How Does Losartan-Hydrochlorothiazide Work?

Losartan-hydrochlorothiazide is a combination of two medicines -- Cozaar® and hydrochlorothiazide. Cozaar is a newer type of blood pressure medicine known as an angiotensin II receptor blocker, or ARB for short. Cozaar blocks angiotensin II receptors, thus decreasing the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By blocking the effects of angiotensin II, Cozaar causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effect of both Cozaar and hydrochlorothiazide, losartan-hydrochlorothiazide can lower blood pressure. And because of its combined effects, losartan-hydrochlorothiazide causes a greater drop in blood pressure than when either medicine is used alone.

Losartan-Hydrochlorothiazide Uses in Children

Losartan-hydrochlorothiazide has not been approved for use in children.

Off-Label Losartan-Hydrochlorothiazide Uses

On occasion, a healthcare provider may recommend losartan-hydrochlorothiazide for treating a condition other than those listed above. This is called an "off-label" use. At this time, there are no universally accepted off-label uses for this drug.
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