Aliskiren and valsartan contains two different medications that work in different ways. Both medications target the renin angiotensin aldosterone system (RAAS), but they work at different points in the process. The RAAS is an important regulator of blood pressure in the body.
Aliskiren is classified as a renin inhibitor, and is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It works to convert angiotensinogen to angiotensin I.
A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Valsartan belongs to a class of drugs called angiotensin II receptor blockers. By blocking angiotensin II, it helps to relax the blood vessels, thereby lowering blood pressure.
Can Children and Teens Use Aliskiren and Valsartan?
Aliskiren and valsartan is not approved for use in children or teens. Talk with your child's healthcare provider about the benefits and risks of using this drug in these age groups.
Is Aliskiren and Valsartan Used for Off-Label Reasons?
On occasion, your healthcare provider may recommend this product for something other than high blood pressure. However, at this time, there are no universally accepted off-label uses for aliskiren and valsartan.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Valturna [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2011 April.
Food and Drug Administration, Center for Drug Evaluation and Research. FDA drug safety communication: new warning and contraindication for blood pressure medicines containing aliskiren (Tekturna) (4/20/2012). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm300889.htm. Accessed April 25, 2012.
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