Candesartan-hydrochlorothiazide is a prescription medication that is used to lower high blood pressure in adults. Candesartan-hydrochlorothiazide is a combination of two medications -- candesartan and hydrochlorothiazide -- and has been shown to cause a greater drop in blood pressure than if either medication was used by itself. Possible side effects of this drug include dizziness, back pain, and upper respiratory infection. It is important to take candesartan-hydrochlorothiazide exactly as it is prescribed in order for it to work properly.
Candesartan-hydrochlorothiazide is a combination of two medicines -- candesartan and hydrochlorothiazide. Candesartan is a newer type of blood pressure medicine known as an angiotensin II receptor blocker, or ARB for short. Candesartan blocks angiotensin II receptors, thus decreasing the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By blocking the effects of angiotensin II, candesartan causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effects of both candesartan and hydrochlorothiazide, candesartan-hydrochlorothiazide can lower blood pressure. Because of its combined effects, candesartan-hydrochlorothiazide causes a greater drop in blood pressure than when either medicine is used alone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Atacand HCT [package insert]. Wilmington, DE: AstraZeneca LP;2012 March.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed December 14, 2012.
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