Hypertension Home > Indapamide and Depression

It is possible to develop certain side effects while taking indapamide, and depression appears to be one of them (occurring in between 1 and 5 percent of people taking the drug). If you are taking indapamide and depression symptoms occur, notify your healthcare provider. If indapamide is indeed the cause of the depression, he or she can recommend another diuretic or blood pressure medication.

Is Depression an Indapamide Side Effect?

There are several possible side effects for people taking indapamide (Lozol®). Depression may be one of them. Indapamide is a diuretic used to treat high blood pressure and fluid retention.
 

Understanding Clinical Trials

Clinical trials are designed to factor out many possible variables in order to understand whether the medicine works and what its possible side effects are. During a study, some people are given the actual medication, while others are given a placebo (which looks like the actual medication but does not contain any of the active ingredients).
 
Side effects may occur in people who are taking the medicine and in people who are taking a placebo. By studying both groups, it is easier to tell which side effects are definitely drug related, which may be drug related, and which have nothing to do with the drug. In clinical studies, depression was reported as one of the possible indapamide side effects, occurring in between 1 and 5 percent of people. However, the exact percentage of people who developed depression was not reported.
 

Indapamide and Depression: Summary

For people taking indapamide, depression may occur. Therefore, if you notice any possible depression symptoms while taking indapamide or if something "just does not seem right," you should talk to your healthcare provider. He or she will be able to diagnose and treat the problem. If your healthcare provider believes the medicine may be causing your symptoms, he or she may recommend another diuretic or blood pressure medicine.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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