Hypertension Home > Side Effects of Propranolol/HCTZ

Because propranolol/HCTZ is an older medication, there is little information available about the specific side effects. However, the two components in it may cause dizziness, fatigue, and nausea, among other things. These reactions are typically minor and easily treated. However, there are other potential problems that should be reported immediately to your healthcare provider, such as difficulty breathing, fainting, or seizures.

An Introduction to Side Effects of Propranolol/HCTZ

Just like any medicine, propranolol/HCTZ (Inderide®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible propranolol/HCTZ side effects. Your healthcare provider can discuss a more complete list with you.)

Serious Propranolol/HCTZ Side Effects

Some side effects of propranolol/HCTZ are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Changes in vision or eye pain 
  • Signs of very low blood pressure (hypotension), such as dizziness, lightheadedness, or fainting
  • Signs of infection, including high fever, sore throat, or aches and pains
  • Mental changes, including depression, hallucinations (seeing or hearing things that are not there), or disorientation
  • Abdominal (stomach) pain, swelling, or bloating
  • Blood in the stool
  • Swelling of the hands, legs, ankles, or feet
  • Sudden weight gain
  • Difficulty breathing
  • An irregular heartbeat
  • Chest pain
  • Signs of liver problems, such as:
    • Dark urine
    • Loss of appetite
    • Fatigue or excessive tiredness
    • Pain in the right upper part of the abdomen (stomach)
    • Yellowing of the whites of the eyes or skin (jaundice)
  • Changes in body electrolytes (such as sodium, potassium, magnesium, and calcium), which may cause the following symptoms:
    • Dry mouth
    • Thirst
    • Weakness
    • Extreme tiredness
    • Restlessness
    • Confusion
    • Muscle pains or cramps
    • Nausea and vomiting
    • Seizures
    • Decreased urination
    • Increased heart rate (tachycardia)
  • Cold, numb, or prickly feelings in the hands or feet
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation




Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.