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More Information on Drug Interactions With Trandate

The following sections explain in detail the potentially negative interactions that can occur when Trandate is combined with any of the drugs listed above.
 
Cimetidine (Tagamet)
If you are taking Trandate and cimetidine, your body may metabolize Trandate differently than intended. This interaction can lead to an increased level of Trandate in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and adjust your Trandate dosage as needed.
 
Calcium Channel Blockers
If Trandate and a calcium channel blocker are combined, your blood pressure may decrease too much or your heart rate may slow dramatically. This can cause symptoms such as a spinning sensation (vertigo), lightheadedness, dizziness, or fainting. You are also at increased risk for developing congestive heart failure or a slow heart rate. If you are taking both of these medications, your healthcare provider may choose to monitor you more closely and, if necessary, adjust your dose.
 
Certain Diabetes Medicines
Taking certain types of diabetes medicines with Trandate may increase the effects of the diabetes medicines, causing blood sugar levels to drop too low (hypoglycemia), or may mask some of the symptoms of hypoglycemia. If you are taking a diabetes medication with Trandate, your healthcare provider may adjust your dosages, monitor you more closely, or both.
 
Tricyclic Antidepressants
People taking Trandate with a tricyclic antidepressant may be at increased risk for tremors. In clinical studies, these tremors were seen in 2.3 percent of people who combined these two medications. Your healthcare provider may choose to monitor you more closely and change your medicines if needed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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