Trandolapril-verapamil ER is a prescription medication that is used to lower blood pressure in adults. While trandolapril-verapamil ER is not a cure for this condition, it does relax the blood vessels of the heart to lower blood pressure and make it easier for the heart to pump blood. There are some potential side effects of trandolapril-verapamil ER, including a headache, constipation, and increased liver enzymes in the blood. Trandolapril-verapamil ER is sold in a tablet form that is taken on a daily basis along with food.
Brand-name Tarka is manufactured by Abbott Laboratories. A generic version is made by Glenmark Generics.
How Does Trandolapril-Verapamil ER Work?
Trandolapril-verapamil ER is a combination of two medicines -- trandolapril (sold under the brand Mavik®) and verapamil ER (sold under several brands and as a generic). Mavik is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. Mavik helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Mavik causes blood vessels to relax.
Verapamil ER is part of a class of drugs called calcium channel blockers. It is a slow release version of verapamil (the ER stands for extended release). Verapamil ER helps to slow down the rate at which calcium moves into the walls of your blood vessels. This in turn helps to relax the vessels, causing a decrease in blood pressure. It also makes it easier for the heart to pump blood.
Because of the effects of both Mavik and verapamil ER, trandolapril-verapamil ER causes a greater drop in blood pressure than when either medicine is used alone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Tarka [package insert]. North Chicago, IL: Abbott Laboratories;2012 August.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed June 18, 2010.
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