Hypertension Home > Zaroxolyn Drug Interactions

When certain medications are taken with Zaroxolyn, drug interactions may occur. Medications that can cause drug interactions include digoxin, other blood pressure medications, and NSAIDs. Some of these interactions may result in certain side effects, such as extremely low blood pressure or low potassium levels. In order to prevent Zaroxolyn drug interactions, your healthcare provider may monitor you more closely and/or adjust your dose of these medications.

Zaroxolyn Drug Interactions: An Overview

Zaroxolyn® (metolazone) can potentially interact with a few of other medicines. Some of the medicines that may lead to Zaroxolyn drug interactions include:
  • Alcohol
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Methenamine (Hiprex®, Urex®)
  • Narcotics, such as codeine, hydrocodone, morphine, and many others
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
  • Salicylates, such as:
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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