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Moduretic and Depression

In clinical studies on Moduretic, depression was reported as a rare side effect, occurring in less than 1 percent of people taking it. However, since the side effect is so rare, it's hard to say if it is caused by the medication or by other factors. If you are taking Moduretic and depression symptoms become apparent, be sure to talk to your healthcare provider.

Is Depression a Moduretic Side Effect?

Several side effects are possible for people taking Moduretic® (amiloride-HCTZ), and depression may be one of them.
Depression is a complaint that is reported rarely in people taking Moduretic (less than 1 percent). This data comes from clinical trials that extensively studied the drug in many people and documented its side effects. The challenge with Moduretic and depression, however, is that given how rarely depression is reported with the drug and how common it is within the general population, it is difficult to tell whether depression is caused by Moduretic, other factors, or a combination of both.

Understanding Clinical Trials

Clinical trials are designed to factor out many possible variables in order to understand whether the medicine works and what its possible side effects are. During a study, some people are given the actual medication, while others are given a placebo (which looks like the actual medication, but does not contain any of the active ingredients).
Side effects occur in people who are taking the medicine and in people who are taking a placebo. By studying both groups, it becomes easier to tell which side effects are definitely drug-related, which may be drug-related, and which have nothing to do with the drug. In clinical studies, depression was reported as one of Moduretic's possible side effects. However, as mentioned, less than 1 percent of people taking it reported depression.
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Moduretic Drug Information

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