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More Info on Interactions With Moduretic

Combining Moduretic with cyclosporine can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment.
Diabetes Medications
Since taking Moduretic may increase your blood sugar, your healthcare provider may need to adjust your dose of diabetes medications (including insulin and oral diabetes medicines).
Moduretic should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
Taking Moduretic with lithium may increase the level of lithium in your blood, potentially increasing your chance of side effects. In general, people taking diuretics, including Moduretic, are not advised to take lithium at the same time. Depending on your individual situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
Combining Moduretic with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about taking these drugs together.
Nonsteroidal Anti-Inflammatory Drugs
Taking Moduretic with NSAIDs can make Moduretic less effective and may increase your risk of side effects. Depending on your situation, your healthcare provider may need to increase your dose of Moduretic or may suggest an alternative to NSAIDs.
In general, products containing potassium should not be used with Moduretic, due to the risk of high potassium levels (hyperkalemia).
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Moduretic Drug Information

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