Moduretic Drug Interactions

If alcohol, barbiturates, or other blood pressure medications are taken with Moduretic, drug interactions can occur. These interactions can lead to problems such as high potassium levels, low blood pressure, and decreased effectiveness of Moduretic. To prevent these and other Moduretic drug interactions, your healthcare provider may adjust your dosages or monitor you more closely.

 

Moduretic Drug Interactions: An Overview

 Moduretic® (amiloride-HCTZ) can potentially interact with a number of other medicines. Some of the medications that can cause Moduretic drug interactions include:
 
  • ACE inhibitors, including:
  • Alcohol
 
  • Angiotensin II receptor blockers (ARBs), such as:
o Eposartan (Teveten®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
 
 
  • Digoxin (Digitek®, Lanoxin®)
 
 
  • Narcotics, such as codeine, hydrocodone, morphine, and many others
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Diclofenac (Cataflam®, Voltaren®)
o Ibuprofen (Motrin®, Advil®)
o Indomethacin (Indocin®, Indocin SR®)
  • Potassium-containing products, such as:
o Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
o Potassium citrate (Urocit-K®, Polycitra-K®)
o Potassium gluconate
o Potassium phosphate (Neutra-Phos-K®, K-Phos®)
o Salt substitutes (used to flavor food)
 
  • Tacrolimus (Prograf®)
 
(Moduretic Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;