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Moduretic Warnings and Precautions

There are several Moduretic warnings and precautions to be aware of before starting the drug. For example, Moduretic can cause changes in your potassium levels, which can be quite dangerous. Also, the drug can cause gout or make it worse. Moduretic warnings and precautions also apply to people with asthma, diabetes, and kidney or liver disease.

Moduretic: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Moduretic® (amiloride-HCTZ) if you have:
  • Liver disease, including cirrhosis
  • Asthma
  • Kidney disease or kidney failure
  • Diabetes
  • Fluid or electrolyte problems
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or trying to become pregnant
  • Breastfeeding.
Tell your healthcare provider about all the medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Moduretic Warnings and Precautions

Warnings and precautions to be aware of prior to taking Moduretic include the following:
  • Moduretic can cause low potassium levels (hypokalemia) or high potassium levels (hyperkalemia). If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:
o Dry mouth
o Thirst
o Weakness
o Lethargy
o Drowsiness
o Restlessness
o Muscle pain or muscle cramps
o Low blood pressure (hypotension)
o Decreased urination
o Rapid heart rate (tachycardia) or irregular heart rhythm (arrhythmia)
o Nausea or vomiting.
Changes in potassium levels can be very dangerous. Because symptoms are not always present, your healthcare provider should measure your potassium levels regularly using a simple blood test during treatment. 
  • In general, people with diabetes should not take Moduretic, as they may be at higher risk for high potassium levels.
  • The drug should be started cautiously in people with liver disease, as Moduretic may increase the risk of hepatic encephalopathy (a brain problem in people with liver disease).
  • Moduretic may cause gout or may make existing gout worse. Make sure to tell your healthcare provider if you have gout or if it becomes worse during treatment.
  • Do not use salt substitutes while taking Moduretic. Salt substitutes usually contain potassium, and combining them with Moduretic can increase your risk of high potassium levels in your blood (hyperkalemia). Herb-type salt substitutes that do not contain potassium are okay to use.
  • If you have asthma, you may be more likely to be allergic to Moduretic.
  • There are a number of medicines that Moduretic can interact with (see Moduretic Drug Interactions).
  • Moduretic is a considered a pregnancy Category B medication. This means that it may be safe to use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug while pregnant (see Moduretic and Pregnancy).
  • It is not known if Moduretic passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before using the drug (see Moduretic and Breastfeeding).
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Moduretic Drug Information

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