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Specific Safety Concerns With Moexipril/HCTZ

Specific Moexipril/HCTZ Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this blood pressure medication include the following:
  • Moexipril/HCTZ can cause a potentially dangerous swelling below the surface of the skin, called angioedema, especially within the first month of treatment. Stop taking moexipril/HCTZ and seek immediate medical care if you develop any symptoms of angioedema, including difficulty breathing or swelling of the face, eyes, lips, tongue, hands, or feet.
  • Moexipril/HCTZ may cause a swelling in the intestines known as intestinal angioedema. The most common symptom of this problem is abdominal (stomach) pain, sometimes with nausea and vomiting. Contact your healthcare provider if you experience abdominal (stomach) pain while taking moexipril/HCTZ.
  • Moexipril/HCTZ may cause excessively low blood pressure, especially in people who are dehydrated, are on a salt-restricted diet, are on kidney dialysis, or have heart disease. Stay hydrated by drinking plenty of fluids while taking moexipril/HCTZ, and let your healthcare provider know if you become dehydrated or experience dizziness, lightheadedness, or fainting.
  • Because it contains hydrochlorothiazide, moexipril/HCTZ may increase blood cholesterol and triglyceride levels. Your healthcare provider may choose to monitor your cholesterol and triglyceride levels with a simple blood test.
  • Moexipril/HCTZ may cause increased blood sugar levels (hyperglycemia) in people with diabetes. If you have diabetes, your healthcare provider may need to adjust the dosages of your diabetes medications. In rare cases, the drug may cause diabetes in people who do not already have the condition.
  • Moexipril/HCTZ can affect blood electrolytes, including sodium, potassium, magnesium, and calcium. Therefore, your healthcare provider may regularly check your electrolyte levels with a blood test while you take this medication. Contact your healthcare provider if you notice any symptoms of an electrolyte imbalance, such as:
    • Dry mouth
    • Feeling thirsty
    • Feeling weak
    • Extreme tiredness
    • Restlessness
    • Low blood pressure, which may cause dizziness or lightheadedness
    • Muscle tiredness, pains, or cramps
    • Nausea and vomiting
    • Decrease in urination
    • Increased heart rate (tachycardia).
  • You should not use potassium supplements, or salt substitutes that contain potassium, without first checking with your healthcare provider. Moexipril/HCTZ may cause an increase in blood potassium levels (hyperkalemia), and taking products that contain potassium may further increase potassium levels. People who have kidney disease or diabetes also have an increased risk for hyperkalemia from moexipril/HCTZ.
  • Moexipril/HCTZ may cause a drop in white blood cells, which could increase your risk for developing an infection. People with kidney disease may have an increased risk for this side effect. Contact your healthcare provider if you develop signs of an infection, such as a fever or sore throat.


  • Drugs that contain hydrochlorothiazide (including this medication) can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. 
Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment (including surgery) may sometimes be necessary.
  • Moexipril/HCTZ may worsen systemic lupus erythematosus (lupus or SLE for short) or, in some cases, may even cause the condition. It may also cause or worsen gout, a form of arthritis characterized by high uric acid levels.
  • If you are having any major surgery, make sure your healthcare provider knows you are taking moexipril/HCTZ.
  • There have been reports of life-threatening allergic reactions occurring in certain people taking medications like moexipril/HCTZ, including people undergoing kidney dialysis and people receiving bee or wasp venom to protect against sting allergies.
  • In very rare cases, ACE inhibitors (such as moexipril/HCTZ) may cause liver failure. If you develop any signs of liver problems, including tiredness or fatigue, dark urine, pain in the right upper part of the abdomen (stomach), or yellowing of the whites of the eyes or skin (jaundice), contact your healthcare provider immediately.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it. Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.


  • One of the medications in moexipril/HCTZ is an angiotensin-converting enzyme (ACE) inhibitor. All ACE inhibitors are known to cause a persistent, nonproductive cough (see Uniretic Cough). If you develop a bothersome cough while taking moexipril/HCTZ, talk to your healthcare provider. He or she may be able to switch you to a different medication.
  • Hydrochlorothiazide (HCTZ), one of the medications in moexipril/HCTZ, passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking this medication (see Uniretic and Breastfeeding).
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Moexipril/HCTZ Medication Information

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