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Understanding How Moexipril/HCTZ Works and Specific Uses

How Does This Medication Work?

The HCTZ component of the medication is a diuretic ("water pill"). It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. The removal of salt and water decreases blood volume, resulting in lower blood pressure.
 
The other component of the drug is moexipril, an angiotensin-converting enzyme inhibitor, or ACE inhibitor for short. It works by blocking the activity of the angiotensin-converting enzyme (ACE), an enzyme found in the body. One of the actions of ACE is to help make a hormone in the body that constricts (narrows) blood vessels. When ACE is blocked, less of the blood vessel-constricting hormone is made, which causes blood vessels to relax and blood pressure to lower.
 

Is It Safe for Children to Take Moexipril/HCTZ?

Moexipril/HCTZ is not approved for use in children. It is not known if this medicine is safe or effective in this age group.
 

Is It Safe for Older Adults to Take Moexipril/HCTZ?

Yes -- older adults can use this medication. However, older adults may be more sensitive to the effects of the medication and, therefore, may need lower dosages.
 

Is It Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend moexipril/HCTZ for something other than the treatment of high blood pressure. This is called an "off-label" use. At this time, there are no widely accepted off-label uses for moexipril/HCTZ.
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Moexipril/HCTZ Medication Information

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