Products That Interfere With Nebivolol
More Information on Interactions With Nebivolol
The following sections explain in detail the potentially negative interactions that can occur when nebivolol is combined with any of the drugs listed above.
Certain Arrhythmia Medications
Combining nebivolol with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia). You may need to be monitored more closely if you take these medications together. In some cases, nebivolol should not be combined with an arrhythmia medication.
Certain Calcium Channel Blockers
Taking nebivolol with certain calcium channel blockers may cause a dangerously slow heart rate (bradycardia). You may need to be monitored more closely if you take these medications together. In some cases, nebivolol should not be combined with a calcium channel blocker.
If you take both clonidine and nebivolol, stopping clonidine (without stopping nebivolol) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. People are often advised to stop taking nebivolol several days before gradually reducing the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider.
CYP 2D6 Inhibitors
Nebivolol is metabolized by a specific liver enzyme known as CYP 2D6. Some other medications (known as CYP 2D6 inhibitors) slow down the activity of this enzyme, causing an increase in the level of nebivolol in the blood. This could potentially lead to serious side effects of nebivolol. Different medications inhibit the enzyme to different extents; some interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining nebivolol with a CYP 2D6 inhibitor.