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Important Guidelines for Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide

Drug Interactions

Olmesartan medoxomil/amlodipine/hydrochlorothiazide may potentially interact with a number of other medications (see Drug Interactions With Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide).

What If I Take an Overdose of Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide?

As with most medications, it is possible to take too much olmesartan medoxomil/amlodipine/hydrochlorothiazide. People who overdose on this medication may experience:
  • Low blood pressure (hypotension)
  • Dizziness
  • A fast heart rate (tachycardia)
  • A low heart rate (bradycardia)
  • Electrolyte problems.
If you happen to overdose on this medication, seek immediate medical attention.
(Click Tribenzor Overdose for more information.)

What Should I Do If I Miss a Dose?

If you forget to take your olmesartan medoxomil/amlodipine/hydrochlorothiazide dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose, and continue with your regular dosing schedule. Do not take a double dose.

How Does This Medication Work?

Olmesartan medoxomil/amlodipine/hydrochlorothiazide is a combination of three different prescription blood pressure medications -- olmesartan, amlodipine, and hydrochlorothiazide.
Olmesartan belongs to a class of medications called angiotensin II receptor blockers (or commonly "ARBs"). Angiotensin II is a vasoconstrictor. This means that it narrows the blood vessels, making it harder for the heart to pump blood through them. As a result, blood pressure increases.
Olmesartan blocks angiotensin II receptors, thus preventing angiotensin II from narrowing the blood vessels. Because the blood vessels stay relaxed, blood pressure lowers.
Amlodipine is part of a class of drugs called calcium channel blockers. It works by slowing down the rate at which calcium moves into the heart and blood vessel walls. This helps to relax the blood vessels, which improves blood flow and lowers blood pressure. It also makes it easier for the heart to pump blood.
Hydrochlorothiazide (or HCTZ for short) is a diuretic, commonly referred to as a "water pill." It works by increasing the amount of salt and water removed from the blood by the kidneys. The extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume, and this results in lower blood pressure.
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Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Information

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