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Safety Concerns With Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide

Specific Precautions and Warnings for Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Olmesartan medoxomil/amlodipine/hydrochlorothiazide can sometimes lower blood pressure too much. This is more likely to happen in people who are on a low-salt diet, who are taking high doses of diuretics ("water pills"), or who are dehydrated (which can happen when you are sick with nausea and vomiting). If you become dizzy, lightheaded, or faint while taking this medication, lie down and contact your healthcare provider.
  • Olmesartan medoxomil/amlodipine/hydrochlorothiazide can affect electrolytes in the blood, including sodium, potassium, magnesium, and calcium. Therefore, your healthcare provider may regularly check your electrolyte levels with a blood test. If you notice any symptoms of electrolyte imbalance, contact your healthcare provider. Symptoms of an electrolyte imbalance may include:
    • Dry mouth
    • Feeling thirsty
    • Feeling weak
    • Extreme tiredness
    • Restlessness
    • Confusion
    • Muscle pains or cramps
    • Nausea and vomiting
    • Seizures
    • Decreased urination
    • Increased heart rate (tachycardia).
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it.
Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.
  • In rare cases, olmesartan medoxomil/amlodipine/hydrochlorothiazide may worsen chest pain or increase the risk for a heart attack in people who have heart disease. This reaction is not common, but is more likely to occur when the medication is first started or the dose is increased.
  • Olmesartan medoxomil/amlodipine/hydrochlorothiazide may worsen systemic lupus erythematosus (lupus or SLE for short) or, in some cases, may even cause the condition. It may also cause or worsen gout, a form of arthritis characterized by high uric acid levels.
  • Olmesartan medoxomil/amlodipine/hydrochlorothiazide may cause increased blood sugar (hyperglycemia) in people with diabetes. If you have diabetes, your healthcare provider may need to adjust the doses of your diabetes medications. In some cases, olmesartan medoxomil/amlodipine/hydrochlorothiazide may cause diabetes in people who do not have the condition.
  • Reports of severe, chronic diarrhea with substantial weight loss have been reported in people taking olmesartan. This side effect can occur months or even years after starting the drug. If you develop such problems, your healthcare provider should check for other problems first, but if no other cause for the diarrhea and weight loss is found, you might need to stop taking this medication.
  • Because it contains hydrochlorothiazide, olmesartan medoxomil/amlodipine/hydrochlorothiazide is more likely than other drugs to cause allergic reactions. This is more common in people with a history of allergies or asthma, but can occur in anyone. Seek medical attention immediately if you develop signs of an allergic reaction, including hives, an unexplained rash, difficulty breathing, or swelling of the face or throat.
  • In general, people who have congestive heart failure (CHF) should not use calcium channel blockers (such as amlodipine, one of the components of the medication). Although amlodipine does not seem to cause problems in people with heart failure, if you do have heart failure, your healthcare provider may choose to monitor you more closely.
  • Because it contains hydrochlorothiazide, olmesartan medoxomil/amlodipine/hydrochlorothiazide may increase blood cholesterol and triglyceride levels. Your healthcare provider may choose to monitor your cholesterol and triglyceride levels with a simple blood test.


  • Drugs that contain hydrochlorothiazide, including this medication, can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment, including surgery, may sometimes be necessary. 


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Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Information

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