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Effects of Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide and Pediatric Uses

How Does It Work?

Olmesartan, one of the components of the medication, belongs to a class of drugs called angiotensin II receptor blockers (or commonly "ARBs"). Angiotensin II is a vasoconstrictor. This means that it causes the blood vessels to narrow, making the heart work harder to pump blood. As a result, blood pressure increases.
 
Olmesartan works by blocking angiotensin II receptors, thus preventing angiotensin II from narrowing the blood vessels. Because the blood vessels stay relaxed, blood pressure lowers.
 
Amlodipine, another component of the medication, is part of a class of drugs called calcium channel blockers. It works by slowing down the rate at which calcium moves into the heart and blood vessel walls. This, in turn, helps to relax the blood vessels, which improves blood flow and lowers blood pressure. It also makes it easier for the heart to pump blood.
 
Hydrochlorothiazide, the last component, is a diuretic, commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume, and this results in lower blood pressure.
 
Because olmesartan medoxomil/amlodipine/hydrochlorothiazide combines the effects of three blood pressure medications, it will typically cause a greater decrease in blood pressure than any of the three medicines used alone. Although olmesartan medoxomil/amlodipine/hydrochlorothiazide lowers blood pressure, it is not a cure for high blood pressure. If you stop taking this medication, it is likely that your blood pressure will increase.
 

Is It Safe for Use in Children?

Olmesartan medoxomil/amlodipine/hydrochlorothiazide is not approved for use in people younger than 18 years of age. It has not been adequately studied in this age group.
 
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Olmesartan Medoxomil/Amlodipine/Hydrochlorothiazide Information

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