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Drugs That Can Interfere With Olmesartan Medoxomil-Hydrochlorothiazide

Interactions With Olmesartan Medoxomil-Hydrochlorothiazide Explained

The following sections explain in detail the potentially negative interactions that can occur when olmesartan medoxomil-hydrochlorothiazide is combined with any of the drugs listed above.
 
Aliskiren
Combining olmesartan medoxomil-hydrochlorothiazide with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required. Aliskiren and olmesartan medoxomil-hydrochlorothiazide should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate to severe kidney problems.
 
ACE Inhibitors
Combining olmesartan medoxomil-hydrochlorothiazide with an ACE inhibitor may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Colesevelam
Colesevelam may decrease the absorption of olmesartan medoxomil-hydrochlorothiazide into the body, perhaps making it less effective. This interaction can be avoided by taking olmesartan medoxomil-hydrochlorothiazide at least four hours before colesevelam.
  
Diuretics
When taking olmesartan medoxomil-hydrochlorothiazide with a diuretic, your blood pressure may decrease too much. This is more likely to occur when olmesartan medoxomil-hydrochlorothiazide is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of olmesartan medoxomil-hydrochlorothiazide, and/or monitor you more closely.
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