Colesevelam may decrease the absorption of olmesartan into the body, perhaps making it less effective. This interaction can be avoided by taking olmesartan at least four hours before colesevelam.

Diuretics

When taking olmesartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when olmesartan is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of olmesartan, and/or monitor you more closely.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Olmesartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and olmesartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.

Potassium Supplements

If you are taking a potassium supplement and olmesartan, the levels of potassium in your blood may become too high. This can cause serious problems. Talk to your healthcare provider about using potassium and olmesartan together in your situation.

Potassium-Sparing Diuretics

If you are taking both olmesartan and a potassium-sparing diuretic, your body may metabolize the drugs differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress closely if this is the case.

Drug Interactions With Olmesartan Article Continues on Next Page >

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD

Last reviewed by: Kristi Monson, PharmD

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