Drugs That Interfere With Penbutolol
Penbutolol Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when penbutolol is combined with any of the drugs listed above.
Drinking alcohol while taking penbutolol may cause coordination difficulties or other problems. Be sure to ask your healthcare provider if you can drink alcohol while taking this medication.
Combining penbutolol with an alpha blocker can increase the risk of dangerously low blood pressure (hypotension). Check with your healthcare provider before taking such medications together.
Calcium Channel Blockers
Taking penbutolol with certain calcium channel blockers may cause dangerously low blood pressure and, for verapamil or diltiazem, a slow heart rate (bradycardia) and heart failure. You may need to be monitored closely if you take these medications together. In some cases, penbutolol should not be combined with a calcium channel blocker.
Certain Arrhythmia Medications
Combining penbutolol with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, penbutolol should not be taken with an arrhythmia medication.
If you take both clonidine and penbutolol, stopping clonidine without stopping penbutolol could increase the risk of dangerously high blood pressure, strokes, and other serious problems. You likely will be advised to stop taking penbutolol several days before gradually reducing the dose of clonidine. Do not attempt this, however, without the approval and supervision of your healthcare provider.