Drug Interactions With Penbutolol

Alcohol, nonsteroidal anti-inflammatory drugs, and certain arrhythmia medications may cause drug interactions with penbutolol. These can cause dangerously low blood pressure, a slow heart rate, and other potentially serious problems. Other medications that can lead interact negatively with this drug include alpha blockers, digoxin, clonidine, and other beta blockers.

An Overview of Penbutolol Interactions

 Penbutolol sulfate (Levatol®) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with penbutolol include:
 
  • Alcohol
  • Alpha blockers (or medications with alpha-blocking activity), such as:
 
 
 
 
  • Certain arrhythmia medications, such as:
 
    • Amiodarone (Cordarone®)
    • Disopyramide (Norpace®, Norpace CR®)
    • Lidocaine (Xylocaine®)
    • Propafenone (Rythmol®)
    • Quinidine
    • Sotalol (Betapace®)
 
 
 
 
 
  • Reserpine.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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