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Specific Drugs That Can React With Propranolol/HCTZ

More Detail on Drug Interactions With Propranolol/HCTZ

The following sections explain in detail the potentially negative reactions that can occur when propranolol/HCTZ is combined with any of the drugs listed above.
 
Alcohol
Drinking alcohol while taking propranolol/HCTZ may lower your blood pressure to unsafe levels, especially when standing up, which can lead to dizziness, lightheadedness, or fainting. In addition, alcohol may increase, or sometimes decrease, the levels of propranolol (one of the medications in propranolol/HCTZ) in your blood. Talk to your healthcare provider before consuming alcohol with this medication.
 
Allopurinol
Propranolol/HCTZ may increase the risk for potentially serious allopurinol side effects. If you take these medications together, your healthcare provider may choose to monitor you more closely for side effects.
 
Alpha Blockers
Adding an alpha blocker to propranolol/HCTZ treatment may increase your risk for extremely low blood pressure. If you are taking propranolol/HCTZ, your healthcare provider may choose to start you on a lower alpha-blocker dosage, and may recommend that you take your first dose at bedtime.
 
Amifostine
Taking propranolol/HCTZ within 24 hours of receiving amifostine could cause your blood pressure to lower to unsafe levels. Talk to your healthcare provider about this possible interaction if you receive amifostine treatment.
 
Amiodarone
Taking amiodarone with propranolol/HCTZ could increase your risk for a dangerously slow heart rate (bradycardia). Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Barbiturates
Taking a barbiturate with propranolol/HCTZ may lower your blood pressure to unsafe levels, especially when moving from a seated to a standing position. The combination may also decrease the levels of propranolol in your blood, potentially making it less effective at lowering blood pressure. Talk to your healthcare provider about this potential interaction before taking these drugs together.
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Propranolol/HCTZ Drug Information

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