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More Drugs That Can React With Propranolol/HCTZ

Combining propranolol/HCTZ with digoxin may cause a dangerously slow heart rate (bradycardia). The combination may also increase your risk for serious digoxin side effects. You may need to be monitored very closely if you take these medications together.
Taking dofetilide with hydrochlorothiazide (one of the medications in propranolol/HCTZ) may cause abnormal heart rhythms, including a potentially dangerous condition called QT prolongation. The manufacturer of dofetilide recommends that these medications not be taken together.
Propranolol/HCTZ may increase the level of everolimus in your blood, increasing your risk for side effects. Your healthcare provider may monitor your everolimus blood levels, and possibly decrease your dose, if you are taking propranolol/HCTZ.
Propranolol/HCTZ may increase blood lithium levels, potentially causing lithium toxicity. Your healthcare provider may choose to monitor your blood lithium levels when you first start taking propranolol/HCTZ, and may need to decrease your lithium dose. Contact your healthcare provider right away if you have symptoms of lithium toxicity, such as confusion, tremors, and coordination problems, while taking these medications together.
Narcotic Pain Relievers
When taking propranolol/HCTZ with a narcotic pain reliever, your blood pressure may lower to unsafe levels, which could cause dizziness, lightheadedness, and fainting. Talk to your healthcare provider about this potential interaction and watch for signs of low blood pressure if you take these medications together.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
When you take propranolol/HCTZ with NSAIDs, propranolol/HCTZ may not be as effective at lowering your blood pressure. Talk to your healthcare provider about this possible interaction before taking these drugs together.
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Propranolol/HCTZ Drug Information

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