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Further Details on Interactions With Propranolol/HCTZ

Other Beta Blockers
Propranolol/HCTZ contains a beta blocker (propranolol). It should not be used with other beta blockers, except under the care and supervision of a healthcare provider.
 
Other Blood Pressure Medications
Taking propranolol/HCTZ with another high blood pressure medication may cause your blood pressure to lower to unsafe levels. Taking multiple blood pressure medications often requires very close monitoring. Talk to your healthcare provider about your individual situation if you take propranolol/HCTZ with other blood pressure medications.
 
Pentoxifylline
Taking propranolol/HCTZ with pentoxifylline may lower your blood pressure to unsafe levels. Your healthcare provider may choose to monitor your blood pressure more closely if you take these drugs together.
 
Reserpine
Combining reserpine with a beta blocker can increase your risk for extremely low blood pressure or a very slow heart rate. Your healthcare provider may monitor you more closely if you take these medications together.
 
Rituximab
Taking propranolol/HCTZ within 12 hours of rituximab could cause your blood pressure to lower to unsafe levels. Talk to your healthcare provider about this possible interaction if you receive rituximab treatment.
 
Theophylline
Theophylline may be less effective when you take it with propranolol/HCTZ. Talk to your healthcare provider about this interaction if you are taking both of these drugs. Your healthcare provider may need to monitor you more closely to make sure theophylline works for you.
 
Topiramate
Hydrochlorothiazide (HCTZ), one of the medications in propranolol/HCTZ, can increase the level of topiramate in the blood. This interaction may increase your risk for topiramate side effects, such as low blood potassium. If you take these medications together, your healthcare provider may need to decrease your topiramate dosage and monitor your blood potassium levels.
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Propranolol/HCTZ Drug Information

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