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Should I Worry About Propranolol/HCTZ Interactions?

Topotecan
Taking propranolol/HCTZ with topotecan may increase the level of topotecan in your blood, increasing your risk for side effects. This interaction is more of a concern with oral dosage forms (topotecan capsules), and is less likely to occur when topotecan is given intravenously (IV).
 
Yohimbe
Yohimbe may decrease the effectiveness of propranolol/HCTZ, meaning it may not work as well to lower your blood pressure. If you are taking propranolol/HCTZ, do not take yohimbe without first talking to your healthcare provider.
 

Final Thoughts

Propranolol/HCTZ has the potential to interact with many different drugs -- far too many to discuss in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific interactions that may apply to you.
 
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Propranolol/HCTZ Drug Information

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