Should I Worry About Propranolol/HCTZ Interactions?
Taking propranolol/HCTZ with topotecan may increase the level of topotecan in your blood, increasing your risk for side effects. This interaction is more of a concern with oral dosage forms (topotecan capsules), and is less likely to occur when topotecan is given intravenously (IV).
Yohimbe may decrease the effectiveness of propranolol/HCTZ, meaning it may not work as well to lower your blood pressure. If you are taking propranolol/HCTZ, do not take yohimbe without first talking to your healthcare provider.