Drugs That Can Interfere With Propranolol Sustained-Release
Interactions With Propranolol Sustained-Release ExplainedThe following sections explain in detail the potentially negative interactions that can occur when propranolol sustained-release is combined with any of the drugs listed above.
Alcohol may increase the level of propranolol sustained-release in the blood, increasing the risk of propranolol sustained-release side effects. Talk with your healthcare provider about whether or not you should drink alcohol (and how much you can drink) while taking propranolol sustained-release.
Combining propranolol sustained-release with an alpha blocker can increase the risk of dangerously low blood pressure (hypotension). Check with your healthcare provider before combining such medications.
Calcium Channel Blockers
Combining propranolol sustained-release with certain calcium channel blockers may cause a dangerously low blood pressure and, for verapamil or diltiazem, a slow heart rate (bradycardia) and heart failure. You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine propranolol sustained-release with a calcium channel blocker.
Certain Arrhythmia Medications
Combining propranolol sustained-release with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia) or very low blood pressure. You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine propranolol sustained-release with an arrhythmia medication.
If you take both clonidine and propranolol sustained-release, stopping clonidine (without stopping propranolol sustained-release) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking propranolol sustained-release several days before you gradually reduce the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to propranolol sustained-release, it is advised to wait several days after stopping clonidine before starting propranolol sustained-release.