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Effects of Quinapril-Hydrochlorothiazide Interactions

More Detail About Quinapril-Hydrochlorothiazide Interactions

The following sections explain in detail the potentially negative interactions that can occur when quinapril-hydrochlorothiazide is combined with any of the drugs listed above.
 
Alcohol
When taking quinapril-hydrochlorothiazide with alcohol, your blood pressure may decrease too much. For your particular situation, make sure to talk with your healthcare provider about drinking alcohol while taking quinapril-hydrochlorothiazide.
 
Aliskiren
Combining quinapril-hydrochlorothiazide with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and quinapril-hydrochlorothiazide should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate to severe kidney problems.
 
Angiotensin II Receptor Blockers (ARBs)
Combining quinapril-hydrochlorothiazide with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Barbiturates
When taking quinapril-hydrochlorothiazide with a barbiturate, your blood pressure may decrease too much. In order to decrease the chances of this quinapril-hydrochlorothiazide interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of quinapril-hydrochlorothiazide, and/or monitor you more closely.
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