Drug Interactions With Quinapril-Hydrochlorothiazide

More Detail on Quinapril-Hydrochlorothiazide Interactions

Diuretics
When you are taking quinapril-hydrochlorothiazide with a diuretic, your blood pressure may decrease too much. This is more likely to occur when quinapril-hydrochlorothiazide is first started. In order to decrease the chances of developing this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of quinapril-hydrochlorothiazide, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking NSAIDs with quinapril-hydrochlorothiazide may add to the damage that your kidneys are already experiencing. Also, NSAIDs may decrease the blood pressure-lowering effects of quinapril-hydrochlorothiazide. For your particular situation, talk to your healthcare provider about using NSAIDs and quinapril-hydrochlorothiazide together.
 
Potassium Supplements or Salt Substitutes With Potassium
If you are taking quinapril-hydrochlorothiazide with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and quinapril-hydrochlorothiazide together.
 
Potassium-Sparing Diuretics
If you are taking both quinapril-hydrochlorothiazide and a potassium-sparing diuretic, your body may metabolize them differently than intended and increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress more closely.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
If you are taking both quinapril-hydrochlorothiazide and lithium, your body may metabolize the drugs differently than intended and increase the lithium levels in the blood. Your healthcare provider may choose to monitor your serum lithium levels more frequently.
(Drug Interactions With Quinapril-Hydrochlorothiazide Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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