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Products That React With Spironolactone-HCTZ

Spironolactone-HCTZ Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when spironolactone-HCTZ is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining spironolactone-HCTZ with ACE inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 
Alcohol
Drinking alcohol while taking spironolactone-HCTZ can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with spironolactone-HCTZ.
 
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Spironolactone-HCTZ should not be taken with amiloride or amiloride-HCTZ. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
 
Angiotensin II Receptor Blockers (ARBs)
Combining spironolactone-HCTZ with ARBs can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 
Barbiturates
Taking spironolactone-HCTZ with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider before using barbiturates with spironolactone-HCTZ.
 
Other Blood Pressure Medicines
When taking spironolactone-HCTZ with another high blood pressure medication, your blood pressure may decrease too much. In order to minimize the chances of this interaction, your healthcare provider may monitor you more closely and change the dose of either medicine.
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