Hypertension Channel
Topics
Medications
Quicklinks
Related Channels

More Spironolactone-HCTZ Interactions

Cholestyramine
Cases of hyperkalemic metabolic acidosis (a potentially dangerous electrolyte and acid imbalance) have been reported in people taking cholestyramine with spironolactone. Check with your healthcare provider before combining these medications.
 
Diabetes Medications
Since taking spironolactone-HCTZ may increase your blood sugar, your healthcare provider may need to adjust your dose of diabetes medications (including insulin and oral diabetes medicines).
 
Digoxin (Digitek, Lanoxin)
Spironolactone-HCTZ should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia) or low potassium levels (hypokalemia), both of which can be especially dangerous for people taking digoxin. Spironolactone-HCTZ can also increase the level of digoxin in your blood.
 
Eplerenone (Inspra)
Spironolactone-HCTZ should not be combined with eplerenone, due to the high risk for dangerously high blood potassium levels (hyperkalemia).
 
Heparin
Combining spironolactone-HCTZ with heparin or low molecular weight heparin medications can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 
Lithium (Eskalith, Lithobid)
Taking spironolactone-HCTZ with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. In general, lithium is not recommended for people taking diuretics, including spironolactone-HCTZ. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose, however, if you are taking both of these medications.
Ouch! 6 Types of Pain You Might Experience When Getting a Stent

Spironolactone Hydrochlorothiazide

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.