More Spironolactone-HCTZ Interactions
Since taking spironolactone-HCTZ may increase your blood sugar, your healthcare provider may need to adjust your dose of diabetes medications (including insulin and oral diabetes medicines).
Digoxin (Digitek, Lanoxin)
Spironolactone-HCTZ should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia) or low potassium levels (hypokalemia), both of which can be especially dangerous for people taking digoxin. Spironolactone-HCTZ can also increase the level of digoxin in your blood.
Spironolactone-HCTZ should not be combined with eplerenone, due to the high risk for dangerously high blood potassium levels (hyperkalemia).
HeparinCombining spironolactone-HCTZ with heparin or low molecular weight heparin medications can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
Lithium (Eskalith, Lithobid)
Taking spironolactone-HCTZ with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. In general, lithium is not recommended for people taking diuretics, including spironolactone-HCTZ. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose, however, if you are taking both of these medications.