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Should I Worry About Interactions With Spironolactone-HCTZ?

Narcotics
Taking spironolactone-HCTZ with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining narcotics with spironolactone-HCTZ.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Combining spironolactone-HCTZ with NSAIDs can make spironolactone-HCTZ less effective and may increase your risk of side effects. Your healthcare provider may need to increase your spironolactone-HCTZ dosage or suggest an alternative to NSAIDs.
 
Potassium-Containing Products
In general, potassium-containing products should not be used with spironolactone-HCTZ, due to the risk of high potassium levels (hyperkalemia).
 
Triamterene Products
Taking spironolactone-HCTZ with medications that contain triamterene can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 

Final Thoughts on Drug Interactions With Spironolactone-HCTZ

It is possible that not all drug interactions with spironolactone-HCTZ were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
 
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