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Drug Interactions With Spironolactone-HCTZ
Some of the medications that may cause negative drug interactions with spironolactone-HCTZ include nonsteroidal anti-inflammatory drugs, narcotics, and ACE inhibitors. Certain interactions can increase your risk of low blood pressure, while others can increase your risk of high potassium levels. To help prevent drug interactions with spironolactone-HCTZ, make sure to tell your healthcare provider about all other medications you are taking.
Spironolactone-HCTZ (Aldactazide®) can potentially interact with a number of other medicines. Some of the medicines that can cause drug interactions with spironolactone-HCTZ include:
- ACE inhibitors, such as:
- Benazepril (Lotensin®), benazepril-hydrochlorothiazide (Lotensin HCT®), or benazepril-amlodipine (Lotrel®)
- Captopril (Capoten®) or captopril-hydrochlorothiazide (Capozide®)
- Enalapril (Vasotec®), enalapril-hydrochlorothiazide (Vaseretic®), or enalapril-felodipine (Lexxel®)
- Fosinopril (Monopril®) or fosinopril-hydrochlorothiazide (Monopril-HCT®)
- Lisinopril (Prinivil®, Zestril®) or lisinopril-hydrochlorothiazide (Prinzide®, Zestoretic®)
- Moexipril (Univasc®) or moexipril/HCTZ (Uniretic®)
- Quinapril (Accupril®) or quinapril-hydrochlorothiazide (Accuretic®, Quinaretic)
- Ramipril (Altace®)
- Trandolapril (Mavik®) or trandolapril-verapamil ER (Tarka®)
- Alcohol
- Amiloride (Midamor®) or amiloride-HCTZ (Moduretic®)
- Angiotensin II receptor blockers (ARBs), such as:
- Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
- Candesartan (Atacand®) or candesartan-hydrochlorothiazide (Atacand HCT®)
- Eprosartan (Teveten®) or eprosartan-hydrochlorothiazide (Teveten® HCT)
- Irbesartan (Avapro®) or irbesartan-hydrochlorothiazide (Avalide®)
- Losartan (Cozaar®) or losartan-hydrochlorothiazide (Hyzaar®)
- Olmesartan (Benicar®), olmesartan-hydrochlorothiazide (Benicar HCT®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis®) or telmisartan-hydrochlorothiazide (Micardis® HCT)
- Valsartan (Diovan®) or valsartan-hydrochlorothiazide (Diovan HCT®)
- Barbiturates, such as:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Other blood pressure medicines
- Cholestyramine (Prevalite®, Questran®, Questran® Light)
- Diabetes medications, including insulin and oral diabetes medicines
- Digoxin (Digitek®, Lanoxin®)
- Eplerenone (Inspra®)
- Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
- Lithium (Eskalith®, Lithobid®)
- Narcotics, such as codeine, hydrocodone, morphine, and many others
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cataflam®, Voltaren®)
- Etodolac (Lodine®)
- Ibuprofen (Motrin®, Advil®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen
- Ketorolac (Toradol®)
- Meloxicam (Mobic®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Nabumetone (Relafen®)
- Oxaprozin (Daypro®)
- Potassium-containing products, such as:
- Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
- Potassium citrate (Urocit-K®, Polycitra-K®)
- Potassium gluconate
- Potassium phosphate (Neutra-Phos-K®, K-Phos®)
- Salt substitutes (used to flavor food)
- Triamterene (Dyrenium®) or triamterene-HCTZ (Dyazide®, Maxzide®).
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Spironolactone Hydrochlorothiazide
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD