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Drug Interactions With Spironolactone-HCTZ

Some of the medications that may cause negative drug interactions with spironolactone-HCTZ include nonsteroidal anti-inflammatory drugs, narcotics, and ACE inhibitors. Certain interactions can increase your risk of low blood pressure, while others can increase your risk of high potassium levels. To help prevent drug interactions with spironolactone-HCTZ, make sure to tell your healthcare provider about all other medications you are taking.

Drug Interactions With Spironolactone-HCTZ: An Overview

Spironolactone-HCTZ (Aldactazide®) can potentially interact with a number of other medicines. Some of the medicines that can cause drug interactions with spironolactone-HCTZ include:


  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Potassium-containing products, such as:
    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)
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