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Side Effects of Spironolactone-HCTZ

Diarrhea or constipation, blurred vision, restlessness, and headache are some of the possible side effects of spironolactone-HCTZ. These side effects are minor in most cases and don't require treatment. However, you should seek medical attention immediately if you develop potentially serious spironolactone-HCTZ side effects, such as signs of low blood pressure (including dizziness or lightheadedness), gout, or breast lumps.

Side Effects of Spironolactone-HCTZ: An Overview

As with any medicine, side effects are possible with spironolactone-HCTZ (Aldactazide®); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, possible side effects with spironolactone-HCTZ. Your healthcare provider can discuss a more complete list of spironolactone-HCTZ side effects with you.)

Side Effects of Spironolactone-HCTZ to Report

Some side effects with spironolactone-HCTZ, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of low blood pressure, such as dizziness, lightheadedness, or fainting spells
  • Eye pain or changes in vision 
  • Signs of low potassium levels (hypokalemia) or high potassium levels (hyperkalemia), such as:
    • Dry mouth
    • Thirst
    • Lethargy
    • Drowsiness
    • Restlessness
    • Muscle pain or muscle cramps
    • Low blood pressure (hypotension)
    • Decreased urination
    • Rapid heart rate (tachycardia), slow heart rate (bradycardia), or irregular heart rhythm (arrhythmia)
    • Nausea or vomiting
    • Abnormal sensations, such as burning, tingling, or pricking
    • Muscle weakness
  • Dehydration
  • Yellowing of the skin or the whites of the eyes (jaundice)
  • Gout
  • Breast lumps
  • Breast enlargement in men (known medically as gynecomastia)
  • Signs of an allergic reaction, such as:
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
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