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Drugs That Interfere With Spironolactone

Spironolactone Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when spironolactone is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining spironolactone with ACE inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
 
Alcohol
Drinking alcohol while taking spironolactone can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with spironolactone.
 
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Spironolactone should not be taken with amiloride or amiloride-HCTZ. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
 
Angiotensin II Receptor Blockers (ARBs)
Combining spironolactone with ARBs can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
 
Barbiturates
Taking spironolactone with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider before using barbiturates with spironolactone.
 
Other Blood Pressure Medicine
When taking spironolactone with another high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this interaction, your healthcare provider may monitor you more closely and change the dose of either medicine.
 
Cholestyramine
Cases of hyperkalemic metabolic acidosis (a potentially dangerous electrolyte and acid imbalance) have been reported in people taking cholestyramine with spironolactone. Check with your healthcare provider before combining these medications.
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