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More Spironolactone Interactions

Digoxin (Digitek, Lanoxin)
Spironolactone should be used carefully in people taking digoxin. Spironolactone can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin. Spironolactone can also increase the level of digoxin in your blood.
Eplerenone (Inspra)
Spironolactone should not be combined with eplerenone, due to the high risk for dangerously high blood potassium levels (hyperkalemia).
Combining spironolactone with heparin or low molecular weight heparin medications can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
Lithium (Eskalith, Lithobid)
Taking spironolactone with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, lithium is usually not recommended to be taken with diuretics, including spironolactone. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose.
Taking spironolactone with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining narcotics with spironolactone.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking spironolactone with NSAIDs can make spironolactone less effective and may increase your risk of side effects (including high potassium levels in your blood). Your healthcare provider may need to increase your dose of spironolactone or suggest an alternative to NSAIDs.
In general, potassium containing products should not be used with spironolactone, due to the risk of high potassium levels (hyperkalemia).
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Spironolactone Medication

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