Drug Interactions With Spironolactone

Alcohol, nonsteroidal anti-inflammatory drugs, and ACE inhibitors may cause drug interactions with spironolactone. When various medications interact with the diuretic, your risk for developing low blood pressure or high potassium levels is increased. Some of the other medications that may cause negative spironolactone interactions include digoxin, triamterene, barbiturates, and other blood pressure medicines.

 

An Overview of Spironolactone Drug Interactions

 Spironolactone (Aldactone®) can potentially interact with a number of other medicines. Some of these medicines that can cause spironolactone drug interactions include:
 
  • ACE inhibitors, including:

 

 

 

 

  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

 

 

  • Potassium containing products, such as:

 

    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)

 

(Drug Interactions With Spironolactone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;