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Is It Dangerous to Use Spironolactone for Acne?

Risks of Treating Acne With Spironolactone

Spironolactone, like any other medication, has side effects (see Spironolactone Side Effects), some of which may be dangerous. Because spironolactone affects hormones, it often causes menstrual changes, such as irregular or absent periods. It is important to keep in mind that spironolactone should not generally be used in pregnant or breastfeeding women (see Aldactone and Pregnancy and Aldactone and Breastfeeding).
 

Final Thoughts

Although it is not approved for this use, spironolactone may be used "off-label" to treat acne in women. It is usually reserved for women who do not respond to other acne treatments. Be sure to talk to your healthcare provider about the risks and benefits of using spironolactone for acne.
 
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