Spironolactone Side Effects

In clinical studies, diarrhea, headache, drowsiness, and impotence were some of the side effects that were reported with spironolactone. Side effects of the medication appear to be mild and do not require treatment in most cases. There are, however, certain side effects of spironolactone that require immediate medical attention, such as signs of high potassium levels, breast lumps, and yellowing of the skin or eyes.

 

An Overview of Spironolactone Side Effects

As with any medicine, side effects can occur with spironolactone (Aldactone®); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If spironolactone side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with spironolactone. Your healthcare provider can discuss a more complete list of spironolactone side effects with you.)
 

Side Effects of Spironolactone to Report

Some side effects with spironolactone, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider.
 These include but are not limited to:
 
  • Signs of high potassium levels (hyperkalemia), including:
 
    • Abnormal sensations, such as burning, tingling, or pricking
    • Muscle weakness
    • Low heart rate (bradycardia)
 
  • Yellowing of the skin or the whites of the eyes (jaundice)
  • Breast enlargement in men (known medically as gynecomastia)
  • Breast lumps
  • Signs of an allergic reaction, including:
 
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
 
(Spironolactone Side Effects Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;