Tekturna HCT and Cough
Is there a connection between Tekturna HCT (aliskiren-HCTZ) and a cough? In clinical studies, up to 1.3 percent of people taking the drug reported a dry, chronic cough as a possible side effect. However, it is difficult to determine whether coughing is caused by Tekturna HCT or other factors. If you are taking Tekturna HCT and coughing occurs, talk to your healthcare provider about possible treatment options.
Tekturna HCT and Coughing: An OverviewTekturna HCT® (aliskiren-HCTZ) is a prescription medication approved to treat high blood pressure. It contains two different medications: hydrochlorothiazide (HCT or HCTZ) and aliskiren. Hydrochlorothiazide is classified as a diuretic, and aliskiren is the first medication classified as a renin inhibitor. Many medications that act on the renin-angiotensin system in the body can cause chronic, dry coughs. During clinical trials, coughing was reported among the possible Tekturna HCT side effects.
How Common Is a Cough With Tekturna HCT?Studies showed that up to 1.3 percent of people taking Tekturna HCT reported a cough, compared with only 0.5 percent of people taking a placebo (a "sugar pill" that does not contain any active ingredients). It is difficult to tell if such a small difference really reflects a true problem; such small differences can easily be due to chance.
A chronic, dry cough is probably due to the aliskiren component of Tekturna HCT, not the hydrochlorothiazide component. Some studies compared Tekturna (just the aliskiren component, without the hydrochlorothiazide) to angiotensin-converting enzyme (ACE) inhibitors, which are blood pressure medications known to cause coughing. Compared to ACE inhibitors, Tekturna was one-half to one-third as likely to cause a cough.