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Are There Risks With Trandate?

Specific Trandate Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Trandate include the following:
  • Trandate can interact with certain medications (see Trandate Drug Interactions).
  • Trandate may hide certain signs of hyperthyroidism. Do not stop taking it abruptly, as this can cause serious symptoms of hyperthyroidism to appear suddenly. Talk with your healthcare provider before stopping treatment so that it can be done in a safe manner.
  • In rare cases, this medication may cause injury to the liver. Most often, this damage is reversible; however, there have been cases of permanent injury or even death. You should tell your healthcare provider right away if you have any possible symptoms of liver problems, including:
    • Yellow eyes or skin (jaundice)
    • Dark urine
    • Vomiting
    • Itching
    • Upper-right abdominal pain (stomach pain).
  • Trandate may cause extreme low blood pressure, a slow heart rate, or both in some people. Symptoms can include dizziness, lightheadedness, and fainting. These symptoms may be more noticeable when going from sitting or lying down to standing.
If you develop any of these symptoms, contact your healthcare provider. Extreme low blood pressure is more likely to occur in people who are taking a diuretic, who are on dialysis, or who have diarrhea or vomiting. Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how Trandate affects you.
  • Using medicines such as Trandate for a long time can, in some cases, lead to heart failure. If you notice any of the following symptoms, contact your healthcare provider:
  • People with congestive heart failure who are taking this drug are at increased risk of the condition becoming worse. This occurs more often when the dosage is increased. Therefore, if your healthcare provider prescribes Trandate because the benefits outweigh the potential risks, he or she may choose to monitor you more closely, especially during dosage changes.
  • People taking Trandate should not stop it abruptly. In clinical studies, this has been shown to increase a person's chances for developing angina (chest pain), heart attack, or serious irregular heart rhythms (arrhythmias). This risk is even greater in people with existing heart disease.
  • This medicine should be used with caution, if at all, in people with certain lung diseases, such as emphysema, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). Medicines like Trandate can affect the lungs and can cause a narrowing of the airways. This risk is increased in people with certain lung diseases. If you develop problems breathing or start wheezing, call your healthcare provider.
  • If you have allergies, Trandate may increase the reaction to the specific allergens, and your body may not respond to the usual doses of epinephrine.
  • For people with diabetes, this medication may mask symptoms of low blood sugar. If you have diabetes, discuss this with your healthcare provider.
  • If you are going to have surgery, let your healthcare provider or dentist know that you are taking Trandate. In general, it is not recommended to stop taking this medication before surgery.
  • Medications like Trandate have been reported to cause intraoperative floppy iris syndrome, a problem with the eyes that can occur during cataract surgery. Stopping Trandate before surgery probably does not prevent this problem from occurring. Before having eye surgery, be sure to tell your healthcare provider if you have been on Trandate.
  • Trandate is a pregnancy Category C medicine, which means that it may not be safe for use during pregnancy. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant while taking this drug (see Trandate and Pregnancy for more information).
  • Trandate passes through breast milk. Therefore, if you are nursing or plan to start, talk to your healthcare provider about your particular situation (see Labetalol and Breastfeeding for more information).
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Trandate Information

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