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Other Drugs That Can Interfere With Trandolapril-Verapamil ER

Certain Arrhythmia Medications
If you are taking trandolapril-verapamil ER with certain arrhythmia medications, your blood pressure or heart rate may decrease too much. Irregular heart rhythms may occur. Check with your healthcare provider before combining trandolapril-verapamil ER with an arrhythmia medication.
 
Certain Statin Medications
Verapamil may increase the level of some statins in the blood, increasing the risk of muscle problems or other statin side effects. When combined with verapamil, the maximum daily dosage of simvastatin is 10 mg, and the maximum daily dosage of lovastatin is 40 mg. Lower-than-normal dosages of atorvastatin may be recommended as well.
  
Clarithromycin
There have been reports of low blood pressure, slow heart rate, and lactic acidosis (a dangerous condition) when trandolapril-verapamil ER was combined with clarithromycin. Check with your healthcare provider before taking these medications together.
 
Cyclosporine
If you are taking trandolapril-verapamil ER and cyclosporine together, your body may metabolize the cyclosporine differently than intended. This can cause an increased level of cyclosporine in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your cyclosporine dose as needed.
 
Digoxin
Taking trandolapril-verapamil ER and digoxin together generally works well as long as the digoxin dose is well-monitored. On occasion, your blood levels of digoxin may increase dramatically when you take these two drugs together. In order to avoid this interaction, your healthcare provider will monitor you more closely and/or adjust your digoxin dosage as needed.
 
Diuretics
When taking trandolapril-verapamil ER with a diuretic, your blood pressure may decrease too much. This is more likely to occur when trandolapril-verapamil ER is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of trandolapril-verapamil ER, and/or monitor you more closely.
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Trandolapril-Verapamil Hydrochloride ER

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