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More Info on Trandolapril-Verapamil ER Interactions

Erythromycin
There have been reports of low blood pressure, slow heart rate, and lactic acidosis (a dangerous condition) when trandolapril-verapamil ER was combined with erythromycin. Check with your healthcare provider before taking these medications together.
 
Injectable Gold
Reactions have been reported in people taking trandolapril-verapamil ER who received gold injections. These reactions included symptoms such as facial flushing, nausea, vomiting, and low blood pressure.
 
Lithium
Trandolapril-verapamil ER may increase the risk of lithium toxicity and may increase the lithium levels in the blood. Your healthcare provider may choose to monitor your blood lithium levels more frequently and may need to adjust your lithium dosage.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Trandolapril-verapamil ER can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and trandolapril-verapamil ER together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Phenobarbital
If you are taking trandolapril-verapamil ER and phenobarbital together, your body may metabolize trandolapril-verapamil ER differently than intended. This can cause a decreased level of trandolapril-verapamil ER in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your trandolapril-verapamil ER dosage if needed.
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