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Effects of Trandolapril-Verapamil ER and Specific Uses

How Does Trandolapril-Verapamil ER Work?

Trandolapril-verapamil ER is a combination of two medicines -- trandolapril (sold under the brand Mavik®) and verapamil ER (sold under several brands and as a generic). Mavik is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. Mavik helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Mavik causes blood vessels to relax.
Verapamil ER is part of a class of drugs called calcium channel blockers. It is a slow release version of verapamil (the ER stands for extended release). Verapamil ER helps to slow down the rate at which calcium moves into the walls of your blood vessels. This in turn helps to relax the vessels, causing a decrease in blood pressure. It also makes it easier for the heart to pump blood.
Because of the effects of both Mavik and verapamil ER, trandolapril-verapamil ER causes a greater drop in blood pressure than when either medicine is used alone.

Is Trandolapril-Verapamil ER Used in Children?

Trandolapril-verapamil ER has not been approved for use in children.

Off-Label Trandolapril-Verapamil ER Uses

On occasion, a healthcare provider may recommend trandolapril-verapamil ER for treating a condition other than those listed above. This is called an "off-label" use. At this time, there are no universally accepted off-label trandolapril-verapamil ER uses.
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