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Products That Can Interfere With Valsartan and Hydrochlorothiazide

More Detail About Valsartan and Hydrochlorothiazide Interactions

The following sections explain in detail the potentially negative interactions that can occur when valsartan and hydrochlorothiazide is combined with any of the drugs listed above.
 
Alcohol
When taking valsartan and hydrochlorothiazide with alcohol, your blood pressure may decrease too much. Talk with your healthcare provider about drinking alcohol while taking valsartan and hydrochlorothiazide in your particular situation.
 
Aliskiren
Combining valsartan and hydrochlorothiazide with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and valsartan and hydrochlorothiazide should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.  
 
ACE Inhibitors
Combining valsartan and hydrochlorothiazide with an ACE inhibitor may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Barbiturates
When taking valsartan and hydrochlorothiazide with a barbiturate, your blood pressure may decrease too much. In order to decrease the chances of this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of valsartan and hydrochlorothiazide, and/or monitor you more closely.
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