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Additional Drugs That Interfere With Valsartan and Hydrochlorothiazide

Bile Acid Sequestrants
Bile acid sequestrants can bind to valsartan and hydrochlorothiazide in the digestive tract and decrease its absorption into the body. Valsartan and hydrochlorothiazide should be taken at least one hour before (or four hours after) the bile acid sequestrant is taken to avoid this drug interaction.
 
Carbamazepine
Combining valsartan and hydrochlorothiazide with carbamazepine may increase the risk of seriously low sodium levels in the blood (hyponatremia). If you take these medications together, your healthcare provider should monitor your blood sodium levels.
 
Corticosteroids
Taking corticosteroids with valsartan and hydrochlorothiazide may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking a corticosteroid with valsartan and hydrochlorothiazide, your healthcare provider may monitor you more closely and/or adjust your dose of these medicines as needed.
 
Diabetes Medications
Valsartan and hydrochlorothiazide may interact with diabetes medications, possibly increasing the chance of high blood sugar (hyperglycemia). If you are taking these drugs together, your healthcare provider may monitor you more closely and/or adjust your dosage of diabetes medications as needed.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Valsartan and hydrochlorothiazide may increase the lithium levels in your blood. For this reason, taking these medications together is generally not recommended. However, they may be combined in certain situations, especially if your lithium levels are carefully monitored.
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