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Effects of Valsartan and Hydrochlorothiazide and Specific Uses

How Does Valsartan and Hydrochlorothiazide Work?

Valsartan and hydrochlorothiazide is a combination of two medicines -- valsartan and hydrochlorothiazide. Valsartan is a newer type of blood pressure medicine known as an angiotensin II receptor blocker, or ARB for short. As the name implies, valsartan blocks angiotensin II receptors. This decreases the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By blocking the effects of angiotensin II, valsartan causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of its combined effects, valsartan and hydrochlorothiazide causes a greater drop in blood pressure than when either medicine is used alone.

Valsartan and Hydrochlorothiazide Uses in Children

Valsartan and hydrochlorothiazide has not been approved for use in children.

Off-Label Valsartan and Hydrochlorothiazide Uses

On occasion, a healthcare provider may recommend valsartan and hydrochlorothiazide for treating a condition other than those listed above. This is called an "off-label" use. At this time, there are no universally accepted off-label valsartan and hydrochlorothiazide uses.
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