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More Details on Interactions With Verelan PM

Chemotherapy Medications
Verelan PM can interact with various chemotherapy medications, causing a variety of effects. It is important to tell all of your healthcare providers about any medications you are taking.
 
Cimetidine (Tagamet)
Cimetidine may increase the level of Verelan PM in your blood, increasing your risk of Verelan PM side effects (although drug interaction studies have shown mixed results). Your healthcare provider may need to adjust your Verelan PM dose or may suggest an alternative to cimetidine.
 
Clonidine (Catapres)
There have been reports of a dangerously slow heart rate in people who took clonidine and verapamil (the active ingredient in Verelan PM) together. Some cases were serious enough to require hospitalization and even the insertion of a pacemaker. Check with your healthcare provider before taking these medications together.
  
Cyclosporine (Gengraf, Neoral, Sandimmune)
Verelan PM may increase the level of cyclosporine in your blood, increasing your risk of side effects. Your healthcare provider should closely monitor your cyclosporine levels and may need to adjust your dosage.
 
CYP 3A4 Inducers
Verelan PM is broken down (metabolized) by certain liver enzymes known as CYP 3A4 enzymes. Other medications (known as CYP 3A4 inducers) that increase the activity of these enzymes can decrease the level of Verelan PM in the blood, making Verelan PM less effective. Check with your healthcare provider before taking Verelan PM with any of these medications. If you have already been taking such medications with Verelan PM, check with your healthcare provider before stopping them.
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