Chemotherapy Medications
Verelan PM can interact with various chemotherapy medications, causing a variety of effects. It is important to tell all of your healthcare providers about any medications you are taking.
Cimetidine (Tagamet)
Cimetidine may increase the level of
Verelan PM in your blood, increasing your risk of
Verelan PM side effects (although drug interaction studies have shown mixed results). Your healthcare provider may need to adjust your Verelan PM dose or may suggest an alternative to cimetidine.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Verelan PM may increase the level of cyclosporine in your blood, increasing your risk of side effects. Your healthcare provider should closely monitor your cyclosporine levels and may need to adjust your dosage.
Digoxin (Digitek, Lanoxin)
Verelan PM may increase the level of digoxin in your blood (although studies have shown conflicting results). Because changes in digoxin levels can be dangerous, your healthcare provider should closely monitor the level of digoxin in your blood and adjust your dosage as necessary. Your healthcare provider should also monitor your heart rate, as Verelan PM and digoxin can both lower your heart rate.
Disopyramide (Norpace)
Because both disopyramide and Verelan PM decrease the heart's ability to pump blood forcefully, disopyramide should not be taken within 48 hours before, or 24 hours after, taking Verelan PM.
Flecainide (Tambocor)
Combining Verelan PM with flecainide may decrease the heart's ability to pump blood forcefully and may decrease the heart rate too much. Your healthcare provider should monitor you closely when combining these two medications.
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